Document Detail


Reciprocal Regulation of Endocytosis and Metabolism.
MedLine Citation:
PMID:  24984778     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The cellular uptake of many nutrients and micronutrients governs both their cellular availability and their systemic homeostasis. The cellular rate of nutrient or ion uptake (e.g., glucose, Fe(3+), K(+)) or efflux (e.g., Na(+)) is governed by a complement of membrane transporters and receptors that show dynamic localization at both the plasma membrane and defined intracellular membrane compartments. Regulation of the rate and mechanism of endocytosis controls the amounts of these proteins on the cell surface, which in many cases determines nutrient uptake or secretion. Moreover, the metabolic action of diverse hormones is initiated upon binding to surface receptors that then undergo regulated endocytosis and show distinct signaling patterns once internalized. Here, we examine how the endocytosis of nutrient transporters and carriers as well as signaling receptors governs cellular metabolism and thereby systemic (whole-body) metabolite homeostasis.
Authors:
Costin N Antonescu; Timothy E McGraw; Amira Klip
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Publication Detail:
Type:  REVIEW     Date:  2014-7-1
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  6     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2014  
Date Detail:
Created Date:  2014-7-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved.
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