Document Detail

A Recipe for Perioperative Cardioprotection: What Matters Most? The Ingredients or the Chef?
MedLine Citation:
PMID:  23136159     Owner:  NLM     Status:  Publisher    
The question of what is the ideal anesthetic for patients with cardiovascular disease has been debated for nearly three decades, and similarly to the case for the use of perioperative beta blockers, the answer appears to be increasingly enigmatic. In the current issue of the Journal, Buse et al(1) report the results of a randomized clinical trial to evaluate the effects of the volatile anesthetic sevoflurane versus the intravenous anesthetic propofol on the incidence of myocardial ischemia in 385 patients with known coronary artery disease or with two or more risk factors for coronary artery disease undergoing non-cardiac surgery. Using continuous electrocardiography and troponin T plasma concentrations as the composite primary endpoint of the study, the incidence of myocardial ischemia was similar in both groups (sevoflurane: 40.8%; propofol: 40.3%); calling into question the current American College of Cardiology/American Heart Association guidelines recommending the use of volatile anesthetics for patients at cardiovascular risk who are undergoing non-cardiac surgery(2).
Judy R Kersten
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-7
Journal Detail:
Title:  Circulation     Volume:  -     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Medical College of Wisconsin, Milwaukee, WI.
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