| Receptor signaling as a regulatory mechanism of DNA repair. | |
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MedLine Citation:
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PMID: 19615770 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Radiotherapy plays a crucial role in the treatment of many malignancies; however, locoregional disease progression remains a critical problem. This has stimulated laboratory research into understanding the basis for tumor cell resistance to radiation and the development of strategies for overcoming such resistance. We know that some cell signaling pathways that respond to normal growth factors are abnormally activated in human cancer and that these pathways also invoke cell survival mechanisms that lead to resistance to radiation. For example, abnormal activation of the epidermal growth factor receptor (EGFR) promotes unregulated growth and is believed to contribute to clinical radiation resistance. Molecular blockade of EGFR signaling is an attractive strategy for enhancing the cytotoxic effects of radiotherapy and, as shown in numerous reports, the radiosensitizing effects of EGFR antagonists correlate with a suppression of the ability of the cells to repair radiation-induced DNA double strand breaks (DSBs). The molecular connection between the EGFR and its governance of DNA repair capacity appears to be mediated by one or more signaling pathways downstream of this receptor. The purpose of this review is to highlight what is currently known regarding EGFR signaling and the processes responsible for repairing radiation-induced DNA lesions that would explain the radiosensitizing effects of EGFR antagonists. |
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Authors:
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Raymond E Meyn; Anapama Munshi; John V Haymach; Luka Milas; K Kian Ang |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-07-15 |
Journal Detail:
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Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Volume: 92 ISSN: 1879-0887 ISO Abbreviation: Radiother Oncol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-15 Completed Date: 2010-01-12 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 8407192 Medline TA: Radiother Oncol Country: Ireland |
Other Details:
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Languages: eng Pagination: 316-22 Citation Subset: IM |
Affiliation:
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Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. rmeyn@mdanderson.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Tumor / radiation effects DNA Breaks, Double-Stranded / radiation effects DNA Damage / radiation effects DNA Repair / physiology*, radiation effects Humans Neoplasms / genetics, radiotherapy Radiation Injuries / prevention & control Radiation Tolerance Radiobiology* Receptor, Epidermal Growth Factor / metabolism, radiation effects* Signal Transduction / radiation effects* |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA006294-440033/CA/NCI NIH HHS; P01 CA06294/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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