| Receptor-mediated transport of human recombinant nerve growth factor from olfactory bulb to forebrain cholinergic nuclei. | |
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MedLine Citation:
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PMID: 1851448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Receptors for nerve growth factor are present in the olfactory bulb and in cholinergic nuclei that send projections to the olfactory bulb. The retrograde transport of 125I-labeled recombinant human nerve growth factor (rhNGF) was demonstrated in the rat 18 h following an injection of [125I]rhNGF into the left olfactory bulb. In each of six animals, [125I]rhNGF label was observed in the ipsilateral horizontal limb of the diagonal band and, in four of the 6 animals, in the vertical limb of the diagonal band. Label was not observed in any other brain region except within the injected olfactory bulb. The transport of label to the diagonal band was blocked by the injection of 170-fold greater concentration of unlabeled rhNGF. Emulsion autoradiography of hematoxylin/eosin counterstained sections revealed silver grains clustered over numerous cell profiles that resembled neurons. In contrast, cerebellar injections of [125I]rhNGF, with or without unlabeled rhNGF, did not label diagonal band neurons, nor the lateral vestibular or red nuclei, from which originate the primary cholinergic afferents to cerebellum. The receptor-dependent transport of NGF from olfactory bulb to forebrain cholinergic nuclei suggests that this projection, unlike pontomesencephalic cholinergic pathways, may be responsive to endogenous NGF or exogenously administered rhNGF. |
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Authors:
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C A Altar; C Bakhit |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research Volume: 541 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-06-19 Completed Date: 1991-06-19 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 82-8 Citation Subset: IM |
Affiliation:
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Developmental Biology, Genentech, Inc., South San Francisco, CA 94080. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography / methods Biological Transport Brain / metabolism* Cricetinae Cricetulus Humans Injections Nerve Growth Factors / metabolism* Olfactory Bulb / metabolism* Parasympathetic Nervous System / metabolism* Receptors, Cell Surface / physiology* Receptors, Nerve Growth Factor Recombinant Proteins |
| Chemical | |
Reg. No./Substance:
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0/Nerve Growth Factors; 0/Receptors, Cell Surface; 0/Receptors, Nerve Growth Factor; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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