| Receptor-mediated oligodeoxynucleotides delivery by estradiol and folic acid polylysine conjugates. | |
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MedLine Citation:
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PMID: 22358703 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The lack of efficient and specific delivery to target cells still limits the potential application of antisense oligodeoxynucleotides as therapeutic agents in cancer disease. We have covalently linked a polylysine chain (10,000-20,000 mW) to compounds as folic acid, retinoic acid, transferrin, insulin and estradiol, to deliver c-myb antisense oligonucleotide into tumor cells. Using these complexes as carriers for the oligodeoxynucleotides can be achieved an increase in their uptake into target cells through a natural endocytosis pathway. |
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Authors:
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G Citro; P Ginobbi; C Szczylik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cytotechnology Volume: 11 ISSN: 0920-9069 ISO Abbreviation: Cytotechnology Publication Date: 1993 Jan |
Date Detail:
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Created Date: 2012-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807027 Medline TA: Cytotechnology Country: Netherlands |
Other Details:
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Languages: eng Pagination: S30-4 Citation Subset: - |
Affiliation:
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Laboratory of Experimental Chemotherapy, Regina Elena Institute for Cancer Research, Viale Regina Elena 291, 00161, Rome, Italy. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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