| Receptor-mediated clearance of tissue kallikreins by rat liver. | |
| | |
MedLine Citation:
|
PMID: 3643709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The exsanguinated, isolated and perfused rat liver clears from the perfusate, at comparable rates, some native tissue kallikreins: human and horse urinary as well as hog pancreatic; the clearance rates were dependent on the initial enzyme concentration in the perfusing fluid. Contrary-wise, rat urinary kallikrein was cleared at negligible rates. Neuraminidase pretreatment of these four kallikreins did not alter their clearance rates. Horse urinary kallikrein binding to isolated prefixed hepatocytes was calcium-dependent and inhibited by asialofetuin (but not by fetuin) and some sugars; these characteristics are compatible with the interpretation that this native tissue kallikrein is recognized by the hepatocyte asialoglycoprotein-receptor. It was calculated that there are about 300,000 receptor sites per cell either using perfusion experiments at 4 degrees C or isolated hepatocytes. |
| | |
Authors:
|
D R Borges; M Kouyoumdjian; E S Prado; J L Prado |
Related Documents
:
|
1842559 - Stimulating effect of thyroid hormone on insulin-like growth factor i release and synth... 8098909 - Catabolism of cysteine, cystine, cysteinesulfinate, and otc by isolated perfused rat hi... 8897849 - Modulation of vascular tone and glycerol levels measured by in situ microdialysis in ra... 7161709 - Correlation of drug conjugative metabolism rates between in vivo and in vitro: glucuron... 17012349 - Red blood cells prevent inhibition of hypoxic pulmonary vasoconstriction by nitrite in ... 17164729 - Ex vivo perfusion with mitomycin c containing solution prolongs heart graft survival in... 8247099 - Cerebellar hypoplasia in the hyperbilirubinemic gunn rat: morphological aspects. 7299669 - Distribution, metabolism, and elimination of phenobarbital in rats: physiologically bas... 9806149 - Rat, but not human, sulfotransferase activates a tamoxifen metabolite to produce dna ad... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Advances in experimental medicine and biology Volume: 198 Pt A ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1986 |
Date Detail:
|
Created Date: 1987-03-11 Completed Date: 1987-03-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 235-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Asialoglycoprotein Receptor Horses Kallikreins / metabolism*, urine Kinetics Liver / metabolism* Perfusion Rats Receptors, Immunologic / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Asialoglycoprotein Receptor; 0/Receptors, Immunologic; EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The liver is the main organ to clear plasma and tissue kallikreins from rat plasma, in vivo.
Next Document: Tissue kallikreins and related enzymes: characterization by model oligopeptides.