Document Detail


Receptor-mediated T cell absorption of antigen presenting cell-derived molecules.
MedLine Citation:
PMID:  21196178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T cells tend to acquire a variety of cell surface molecules derived from antigen presenting cells (APCs). The molecule uptake occurs mainly during direct T/APC contact and is instigated by specific receptor/ligand interactions, such as T cell receptor (TCR) with a cognate peptide/MHC complex (pMHC) or CD28 with B7. The acquired molecules are targeted for internalization and degradation in the lysosome. Nevertheless, those molecules are expressed on the surface of T cells for a period of time. The presentation of APC-derived ligands by T cells exhibited a multitude of immunological effects via antigen-specific T/T interaction upon recognition of the absorbed antigens by contact with other T cells. Ligand uptake also occurs via absorption of membrane vesicles shed from APCs prior to contact (e.g., exosomes and plasma membrane-derived vesicles). As in ligand absorption via direct T/APC interaction, the absorption of pre-formed membrane vesicles is also dependent on specific receptor/ligand interactions. In this review, biological mechanisms underlying the ligand absorption process as well as the biological significance and application of the event will be discussed.
Authors:
Inkyu Hwang; DaLim Ki
Related Documents :
21114488 - Estradiol-dependent perforin expression by human regulatory t-cells.
2784488 - Vicia villosa agglutinin separates freshly isolated peyer's patch t cells into interleu...
21540458 - Calcineurin-dependent negative regulation of cd94/nkg2a expression on naive cd8+ t cells.
8536788 - Increased production of interleukin-6 by t lymphocytes from patients with multiple myel...
2990738 - Segregation of the nk-sensitive phenotype in human x mouse somatic cell hybrids reveals...
9012838 - Peripheral deletion of rheumatoid factor b cells after abortive activation by igg.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  16     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-04-21     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-21     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. inkyu@scripps.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Antigen-Presenting Cells / immunology*
Exosomes / physiology
Humans
Ligands
Lymphocyte Activation
Mice
Receptors, Antigen, T-Cell / immunology
T-Lymphocytes / immunology*
Grant Support
ID/Acronym/Agency:
AI066146/AI/NIAID NIH HHS; MH084690-3R74G/MH/NIMH NIH HHS; MH085707-01/MH/NIMH NIH HHS; R01 AI066146-01A1/AI/NIAID NIH HHS; R01 AI066146-02/AI/NIAID NIH HHS; R01 AI066146-03/AI/NIAID NIH HHS; R56 AI066146-04/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Ligands; 0/Receptors, Antigen, T-Cell
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Molecular imaging metrics to evaluate response to preclinical therapeutic regimens.
Next Document:  A minireview: the role of MAPK/ERK and PI3K/Akt pathways in thyroid follicular cell-derived neoplasm...