Document Detail

Receptor mechanisms of bradykinin-mediated activation of prenodal lymphatic smooth muscle.
MedLine Citation:
PMID:  9657359     Owner:  NLM     Status:  MEDLINE    
We have previously shown that several endogenous vasoactive agents constrict prenodal lymph vessels in the canine forelimb. In this study, we assessed the receptor mechanisms by which bradykinin activates lymphatic smooth muscle. Intralymphatic (i.l.) infusion of bradykinin at concentrations of 3.82 x 10(-6), 3.82 x 10(-5) and 3.82 x 10(-4) molar significantly increased lymphatic perfusion pressure. To determine the potential role of lymphatic alpha-receptors in this response, we infused bradykinin at a concentration of 3.82 x 10(-4) molar i.l. before and during intra-arterial (i.a.) phentolamine administration. Prior to phentolamine, bradykinin resulted in a doubling of the lymphatic perfusion pressure. Phentolamine alone had no effect on the resting lymphatic pressure, but significantly reduced forelimb arterial pressures. When the infusion of bradykinin was repeated during phentolamine administration, there was no significant change in the lymphatic perfusion pressure. To determine the subclass of alpha-adrenergic receptors involved in this response, we infused bradykinin and the alpha1-receptor agonist phenylephrine i.l. before and during administration of i.a. prazosin, a specific alpha1-receptor antagonist, i.a. Prior to prazosin, both phenylephrine and bradykinin significantly increased lymphatic perfusion pressure. During prazosin administration, neither phenylephrine nor bradykinin significantly altered the lymphatic perfusion pressure. These data indicate that bradykinin-mediated increases in prenodal lymphatic smooth muscle tone are mediated by lymphatic alpha1-adrenergic receptors.
D E Dobbins; A J Premen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Regulatory peptides     Volume:  74     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-09-28     Completed Date:  1998-09-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Adrenergic alpha-Antagonists / pharmacology
Bradykinin / pharmacology*
Lymphatic System / drug effects*
Muscle Contraction / drug effects*
Muscle, Smooth / drug effects*
Phentolamine / pharmacology
Phenylephrine / pharmacology
Prazosin / pharmacology
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 19216-56-9/Prazosin; 50-60-2/Phentolamine; 58-82-2/Bradykinin; 59-42-7/Phenylephrine

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