Document Detail

Receptor-like activity of a monoclonal anti-idiotypic antibody against an anti-acetylcholine receptor antibody.
MedLine Citation:
PMID:  6729408     Owner:  NLM     Status:  MEDLINE    
A monoclonal anti-idiotypic antibody against an anti-acetylcholine receptor antibody from a patient with myasthenia gravis was shown to bind the cholinergic ligand alpha-bungarotoxin. This binding could be inhibited by other cholinergic ligands, both antagonists and agonists. The anti-idiotype was also able to elicit the production of anti-receptor antibodies in mice. Thus, the anti-idiotype had functional properties similar to those of the original antigen, the acetylcholine receptor.
A K Lefvert; B W Fulpius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  19     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-07-18     Completed Date:  1984-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  485-9     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal / administration & dosage,  physiology*
Antibody Formation
Binding Sites, Antibody* / drug effects
Binding, Competitive
Bungarotoxins / metabolism
Carbachol / metabolism
Gallamine Triethiodide / metabolism
Immunoglobulin Idiotypes / immunology*
Mice, Inbred BALB C
Receptors, Cholinergic / immunology*
Tubocurarine / metabolism
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Binding Sites, Antibody; 0/Bungarotoxins; 0/Immunoglobulin Idiotypes; 0/Receptors, Cholinergic; 51-83-2/Carbachol; 57-95-4/Tubocurarine; 65-29-2/Gallamine Triethiodide

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