| Receptor heteromerization and drug discovery. | |
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MedLine Citation:
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PMID: 20060175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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G-protein-coupled receptors (GPCRs) are membrane proteins that convert extracellular information into intracellular signals. They are involved in many biological processes and therefore represent powerful targets to modulate physiological and pathological states. Recent studies have demonstrated that GPCR activity is regulated by several mechanisms. Among these, protein-protein interactions (and in particular interactions with other receptors leading to heteromerization) has been shown to have an important role in modulating GPCR function. This has expanded their repertoire of signaling and added a new level of regulation to their physiological roles. Emerging studies provide evidence for tissue-specific and disease-specific receptor heteromerization. This suggests that heteromers represent novel drug targets for the identification of selective compounds with potentially fewer side-effects. |
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Authors:
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Raphael Rozenfeld; Lakshmi A Devi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-01-07 |
Journal Detail:
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Title: Trends in pharmacological sciences Volume: 31 ISSN: 1873-3735 ISO Abbreviation: Trends Pharmacol. Sci. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-06-02 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7906158 Medline TA: Trends Pharmacol Sci Country: England |
Other Details:
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Languages: eng Pagination: 124-30 Citation Subset: IM |
Copyright Information:
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2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY10029, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Discovery
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methods* Ligands Protein Binding Protein Multimerization Receptors, G-Protein-Coupled* / metabolism, physiology Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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1P50GM071558-01A27398/GM/NIGMS NIH HHS; AA017067/AA/NIAAA NIH HHS; DA08862/DA/NIDA NIH HHS; DA19521/DA/NIDA NIH HHS; K05 DA019521-05/DA/NIDA NIH HHS; R01 DA008863-15/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Receptors, G-Protein-Coupled |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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