Document Detail


Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.
MedLine Citation:
PMID:  10835680     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Accumulation of fibrils composed of amyloid A in tissues resulting in displacement of normal structures and cellular dysfunction is the characteristic feature of systemic amyloidoses. Here we show that RAGE, a multiligand immunoglobulin superfamily cell surface molecule, is a receptor for the amyloidogenic form of serum amyloid A. Interactions between RAGE and amyloid A induced cellular perturbation. In a mouse model, amyloid A accumulation, evidence of cell stress and expression of RAGE were closely linked. Antagonizing RAGE suppressed cell stress and amyloid deposition in mouse spleens. These data indicate that RAGE is a potential target for inhibiting accumulation of amyloid A and for limiting cellular dysfunction induced by amyloid A.
Authors:
S D Yan; H Zhu; A Zhu; A Golabek; H Du; A Roher; J Yu; C Soto; A M Schmidt; D Stern; M Kindy
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature medicine     Volume:  6     ISSN:  1078-8956     ISO Abbreviation:  Nat. Med.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-24     Completed Date:  2000-07-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9502015     Medline TA:  Nat Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  643-51     Citation Subset:  IM    
Affiliation:
Departments of Pathology, Physiology, and Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA. sdy1@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Amyloid / metabolism
Amyloidosis / metabolism*,  pathology
Animals
Cell Line
Glycoproteins / metabolism,  pharmacology
Heme Oxygenase (Decyclizing) / genetics
Heme Oxygenase-1
Humans
Interleukin-6 / genetics
Macrophage Colony-Stimulating Factor / genetics
Membrane Proteins
Mice
Mice, Inbred C57BL
Monocytes / cytology,  metabolism
NF-kappa B / metabolism
Rabbits
Receptors, Immunologic / genetics,  metabolism*
Serum Amyloid A Protein / metabolism*
Silver Nitrate / metabolism,  pharmacology
Spleen / metabolism,  pathology
Grant Support
ID/Acronym/Agency:
AG00690/AG/NIA NIH HHS; AG12891/AG/NIA NIH HHS; AG14103/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Amyloid; 0/Glycoproteins; 0/Interleukin-6; 0/Membrane Proteins; 0/NF-kappa B; 0/Receptors, Immunologic; 0/Serum Amyloid A Protein; 0/advanced glycosylation end-product receptor; 0/amyloid enhancing factor; 106602-62-4/amylin; 7761-88-8/Silver Nitrate; 81627-83-0/Macrophage Colony-Stimulating Factor; EC 1.14.99.3/HMOX1 protein, human; EC 1.14.99.3/Heme Oxygenase (Decyclizing); EC 1.14.99.3/Heme Oxygenase-1; EC 1.14.99.3/Hmox1 protein, mouse
Comments/Corrections
Comment In:
Nat Med. 2000 Jun;6(6):633-4   [PMID:  10835676 ]

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