Document Detail


Receptor concentrations for estradiol and progesterone in surgically induced endometriosis in the rat.
MedLine Citation:
PMID:  8070595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to obtain more detailed information about the validity of the rat as an endometriotic experimental model, endometriosis was surgically induced in 48 female Wistar rats, and the estrogen (ERc) and progesterone (PRc) receptor concentrations present in experimental endometriosis and endometrium were compared in the four estrous phases (n = 12). Lower values of ERc were found in endometriosis than in endometrium (proestrus, 156.27 +/- 24.09 vs. 195.27 +/- 32.13 pmol/g tissue, P < 0.05; estrus, 302.33 +/- 45.16 vs. 335.67 +/- 44.82 pmol/g tissue, P < 0.05; metestrus, 166.60 +/- 26.09 vs. 193.30 +/- 22.04 pmol/g tissue, P < 0.05; diestrus, 130.27 +/- 20.58 vs. 135.81 +/- 16.25 pmol/g tissue, P > 0.05; Student's t-test). As in the case of ERc, lower PRc were observed in endometriotic than in endometrial tissues (proestrus, (proestrus, 137.83 +/- 22.64 vs. 176.54 +/- 21.78 pmol/g tissue, P < 0.05; estrus, 242.10 +/- 34.78 vs. 286.20 +/- 31.74 pmol/g tissue, P < 0.05; metestrus, 194.36 +/- 35.08 vs. 224.73 +/- 20.21 pmol/g tissue, P < 0.05; diestrus, 147.72 +/- 26.21 vs. 147.33 +/- 22.65 pmol/g tissue, P > 0.05; Student's t-test). Similar ERc/PRc ratios were found for both the endometriotic and the endometrial tissues (proestrus, 1.14 +/- 0.07 vs. 1.08 +/- 0.09, P > 0.05; estrus, 1.29 +/- 0.19 vs. 1.21 +/- 0.18, P > 0.05; metestrus, 0.87 +/- 0.14 vs. 0.89 +/- 0.11 P > 0.05; diestrus, diestrus, 0.89 +/- 0.06 vs. 0.92 +/- 0.06, P > 0.05; Student's t-test, NS).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J Ortega-Moreno
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  54     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-27     Completed Date:  1994-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  IM    
Affiliation:
Department of Animal Pathology, University of Zaragoza, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal*
Endometriosis*
Endometrium / chemistry*
Estrus
Female
Rats
Rats, Wistar
Receptors, Estrogen / analysis*
Receptors, Progesterone / analysis*
Chemical
Reg. No./Substance:
0/Receptors, Estrogen; 0/Receptors, Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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