Document Detail


Receptor-activating autoantibodies and disease: preeclampsia and beyond.
MedLine Citation:
PMID:  21895478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The research reviewed in this article provides examples of autoantibody-mediated receptor activation that likely contributes to disease. The classic example is Graves' hyperthyroidism, in which autoantibodies activate the thyroid-stimulating hormone receptor resulting in overproduction of thyroid hormones. Other compelling examples come from the cardiovascular literature and include agonistic autoantibodies targeting the cardiac β(1)-adrenergic receptor, which are associated with dilated cardiomyopathy. Autoantibodies capable of activating α(1)-adrenergic receptors are associated with refractory hypertension and cardiomyopathy. A prominent example is preeclampsia, a hypertensive disease of pregnancy, characterized by the presence of autoantibodies that activate the major angiotensin receptor, AT(1). AT(1) receptor-activating autoantibodies are also observed in kidney transplant recipients suffering from severe vascular rejection and malignant hypertension. AT(1) receptor-activating autoantibodies and antibodies that activate the endothelin-1 receptor, ET(A), are prevalent in individuals diagnosed with systemic sclerosis. Thus, the presence of agonistic autoantibodies directed to G protein-coupled receptors has been observed in numerous cardiovascular disease states. Rapidly emerging evidence indicates that receptor-activating autoantibodies contribute to disease, and that efforts to detect and remove these pathogenic autoantibodies or block their actions will provide promising therapeutic possibilities.
Authors:
Yang Xia; Rodney E Kellems
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of clinical immunology     Volume:  7     ISSN:  1744-8409     ISO Abbreviation:  Expert Rev Clin Immunol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-07     Completed Date:  2011-12-30     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101271248     Medline TA:  Expert Rev Clin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  659-74     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, TX 77030, USA. yang.xia@uth.tmc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoantibodies / immunology*
Female
Humans
Pre-Eclampsia / immunology*,  pathology,  therapy
Pregnancy
Receptor, Angiotensin, Type 1 / immunology*
Receptor, Endothelin A / immunology*
Scleroderma, Systemic / immunology,  pathology,  therapy
Grant Support
ID/Acronym/Agency:
HD34130/HD/NICHD NIH HHS; HL076558/HL/NHLBI NIH HHS; R01 HD034130-14/HD/NICHD NIH HHS; R01 HD034130-15/HD/NICHD NIH HHS; RC4 HD067977-01/HD/NICHD NIH HHS; RC4HD067977/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Receptor, Angiotensin, Type 1; 0/Receptor, Endothelin A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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