Document Detail

Receptor (CD46) modulation and complement-mediated lysis of uninfected cells after contact with measles virus-infected cells.
MedLine Citation:
PMID:  8523534     Owner:  NLM     Status:  MEDLINE    
Recently, it has been observed that the infection of human target cells with certain measles virus (MV) strains leads to the downregulation of the major MV receptor CD46. Here we report that CD46 downregulation can be rapidly induced in uninfected cells after surface contact with MV particles or MV-infected cells. Receptor modulation is detectable after 30 min of cocultivation of uninfected cells with MV-infected cells and is complete after 2 to 4 h, a time after which newly synthesized MV hemagglutinin (MV-H) cannot be detected in freshly infected target cells. This contact-mediated receptor modulation is also induced by recombinant MV-H expressed by vaccinia virus and is inhibitable with antibodies against CD46 and MV-H. By titrating the effect with MV Edmonston strain-infected cells, a significant contact-mediated CD46 modulation was detectable up to a ratio of 1 infected to 64 uninfected cells. As a result of CD46 downregulation, an increased susceptibility of uninfected cells for complement-mediated lysis was observed. This phenomenon, however, is MV strain dependent, as observed for the downregulation of CD46 after MV infection. These data suggest that in acute measles or following measles vaccination, uninfected cells might also be destroyed by complement after contacting an MV-infected cell.
J Schneider-Schaulies; J J Schnorr; J Schlender; L M Dunster; S Schneider-Schaulies; V ter Meulen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of virology     Volume:  70     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-01-25     Completed Date:  1996-01-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-63     Citation Subset:  IM    
Institut für Virologie und Immunbiologie, Würzburg, Germany.
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MeSH Terms
Antigens, CD / immunology,  metabolism*
Antigens, CD46
Cell Line
Cell Membrane / metabolism
Cercopithecus aethiops
Complement Hemolytic Activity Assay
Complement System Proteins / immunology*
Hemagglutinins, Viral / immunology,  metabolism
Hydrogen-Ion Concentration
Measles virus / immunology*,  isolation & purification,  physiology
Membrane Glycoproteins*
Receptors, Virus / metabolism*
Tumor Cells, Cultured
Vero Cells
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD46; 0/CD46 protein, human; 0/Hemagglutinins, Viral; 0/Membrane Glycoproteins; 0/Receptors, Virus; 0/hemagglutinin protein G, measles virus; 9007-36-7/Complement System Proteins

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