Document Detail

Recent trends in the prevalence and secondary prevention of Down's syndrome.
MedLine Citation:
PMID:  2528127     Owner:  NLM     Status:  MEDLINE    
Examination of data from the Glasgow Registry of Congenital Anomalies indicated that 184 infants with Down's syndrome were born (live or still) to mothers residing in the Greater Glasgow Health Board area between 1974 and 1986 inclusive. This represents a period prevalence of 1.1 per 1000 total births. Despite a strongly positive correlation between prevalence and maternal age, most of the Down's syndrome infants were born to mothers aged under 35 years. There was no evidence either of a recent decline in the annual prevalence rate or of a changing pattern of risk in relation to maternal age. Antenatal diagnosis resulted in the termination of less than a tenth of all Down's syndrome pregnancies. These findings point to a need for further aetiological research, for continued epidemiological monitoring, for an improvement in the relatively low uptake of amniocentesis by older mothers, and for the development of a screening test which can be offered to the entire pregnant population.
D H Stone; K Rosenberg; J Womersley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  3     ISSN:  0269-5022     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-04     Completed Date:  1989-10-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  278-83     Citation Subset:  IM    
Social Paediatric and Obstetric Research Unit, University of Glasgow, UK.
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MeSH Terms
Cross-Sectional Studies
Down Syndrome / epidemiology*,  prevention & control
Infant, Newborn
Maternal Age
Prenatal Diagnosis
Risk Factors

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