| Recent trends in cystic fibrosis-related diabetes. | |
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MedLine Citation:
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PMID: 20489612 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To provide an updated literature review highlighting important aspects of cystic fibrosis-related diabetes (CFRD) including epidemiology, pathogenesis, complications, screening, and management. RECENT FINDINGS: Although CFRD continues to be associated with increased rates of mortality in the cystic fibrosis (CF) population, this has improved over the past several years, and the previous sex difference is no longer present. Recent studies support that CFRD is primarily caused by insulin deficiency due to loss of beta cells, which may occur via a number of mechanisms including oxidative stress. Aggressive screening programs with oral-glucose tolerance testing and early treatment with insulin for patients with CFRD with or without fasting hyperglycemia have led to improvements in nutritional states and lung function. Oral agents do not appear to be effective in CFRD. SUMMARY: CFRD is the most common comorbidity in the CF population and is associated with microvascular complications and protein catabolism leading to worse health outcomes. Recognition of glycemic abnormalities through aggressive screening has led to improvements in nutritional status, pulmonary function, and mortality rates. |
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Authors:
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Brandon M Nathan; Theresa Laguna; Antoinette Moran |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in endocrinology, diabetes, and obesity Volume: 17 ISSN: 1752-2978 ISO Abbreviation: Curr Opin Endocrinol Diabetes Obes Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-06-30 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101308636 Medline TA: Curr Opin Endocrinol Diabetes Obes Country: England |
Other Details:
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Languages: eng Pagination: 335-41 Citation Subset: IM |
Affiliation:
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Divisions of Pediatric Endocrinology, University of Minnesota, Minneapolis, Minnesota, USA. natha039@umn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Comorbidity Cystic Fibrosis / complications*, diagnosis, epidemiology, mortality Diabetes Mellitus, Type 2 / diagnosis, epidemiology, etiology*, therapy Diagnostic Techniques, Endocrine / trends Guidelines as Topic Humans Models, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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