Document Detail

Recent topics related to human herpesvirus 6 cell tropism.
MedLine Citation:
PMID:  19290911     Owner:  NLM     Status:  MEDLINE    
Human herpesvirus 6 (HHV-6) is a T lymphotropic herpes virus that is categorized into two variants, A (HHV-6A) and B (HHV-6B), on the basis of distinct genetic, immunological and biological characteristics. HHV-6 uses human CD46 as a cellular receptor. Without viral replication, HHV-6A induces cell-cell fusion between cells expressing human CD46. Some HHV-6B strains can also induce CD46-mediated cell-cell fusion. A multiple glycoprotein complex composed of glycoprotein (g) H-gL complexed with gQ1 and gQ2 has been identified, and found to be a viral ligand for the human CD46 receptor. Moreover, a novel complex consisting of gH/gL/gO, which does not associate with CD46, has also been identified. The evidence suggests that an additional receptor for HHV-6B or both variants may play a role in determining the cell tropism of this virus. Finally, cholesterol in the HHV-6 envelope and plasma membrane of the host cells plays an important role in HHV-6 entry, although how this function relates to cell-envelope fusion remains to be elucidated.
Yasuko Mori
Publication Detail:
Type:  Journal Article; Review     Date:  2009-03-12
Journal Detail:
Title:  Cellular microbiology     Volume:  11     ISSN:  1462-5822     ISO Abbreviation:  Cell. Microbiol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-11     Completed Date:  2009-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883691     Medline TA:  Cell Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1001-6     Citation Subset:  IM    
Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Japan.
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MeSH Terms
Antigens, CD46 / metabolism
Cholesterol / metabolism
Herpesvirus 6, Human / physiology*
Protein Binding
Receptors, Virus / metabolism
Viral Envelope Proteins / metabolism
Virus Attachment*
Virus Internalization*
Reg. No./Substance:
0/Antigens, CD46; 0/Receptors, Virus; 0/Viral Envelope Proteins; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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