Document Detail


Recent studies of the cellular uptake of long chain free fatty acids.
MedLine Citation:
PMID:  7974967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the last 12 years, we and others have demonstrated that fatty acid uptake is not simply a passive, diffusive process, but an interesting, facilitated mechanism the regulation of which has specific implications for disease. This work also tells another tale. Our earliest experiments were called "squirt studies" by our technician because they involved "squirting" a bolus of labelled metabolite intravenously into one limb of the subject and drawing blood samples from another. These studies were conducted in patients, and later in intact animals. From these we moved progressively to investigations in isolated perfused organs, isolated cells, and sub-cellular organelles and membrane vesicles; to the chemistry of membrane proteins, and most recently, to studies combining recombinant DNA technology with cellular biologic studies of controlled differentiation in tissue culture (Figure 5). The work has been not only a continuing process of scientific investigation but, for the investigators, an on-going process of self-education.
Authors:
P D Berk; S L Zhou; D Stump; C L Kiang; L M Isola
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Transactions of the American Clinical and Climatological Association     Volume:  105     ISSN:  0065-7778     ISO Abbreviation:  Trans. Am. Clin. Climatol. Assoc.     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-21     Completed Date:  1994-12-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7507559     Medline TA:  Trans Am Clin Climatol Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-89     Citation Subset:  IM    
Affiliation:
Department of Medicine (Divisions of Liver Diseases and Hematology), Mount Sinai School of Medicine, New York, NY 10029.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells / metabolism*
Fatty Acids, Nonesterified / metabolism*
Humans
Grant Support
ID/Acronym/Agency:
DK-26438/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified
Comments/Corrections

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