Document Detail


Recent progress in the metabolic engineering of alkaloids in plant systems.
MedLine Citation:
PMID:  22954587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plant alkaloids have a rich chemical ecology that has been exploited for medicinal purposes for thousands of years. Despite being highly represented within today's pharmacopoeia, relatively little is known about the biosynthesis, regulation and transport of these molecules. Understanding how nature synthesizes plant alkaloids will enhance our ability to overproduce--that is, to metabolically engineer--these medicinally useful compounds as well as new-to-nature compounds (with potentially improved bioactivity) derived from these natural scaffolds. Recent progress in the metabolic engineering of nitrogen-containing plant natural products--specifically the monoterpene indole alkaloids, the benzylisoquinoline alkaloids and the glucosinolates--was made possible through the characterization of various components in both native and engineered enzymatic pathways. The subsequent reconfiguration and tuning of these biological 'parts' has enabled the production of selected products at increasingly higher titers.
Authors:
Weslee S Glenn; Weerawat Runguphan; Sarah E O'Connor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-09-03
Journal Detail:
Title:  Current opinion in biotechnology     Volume:  24     ISSN:  1879-0429     ISO Abbreviation:  Curr. Opin. Biotechnol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-05-17     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  9100492     Medline TA:  Curr Opin Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  354-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / biosynthesis,  chemistry,  metabolism*
Benzylisoquinolines / chemistry,  metabolism
Biological Products / chemistry,  metabolism
Cytochrome P-450 Enzyme System / metabolism
Glucosinolates / chemistry,  metabolism
Indole Alkaloids / chemistry,  metabolism
Metabolic Engineering*
Monoterpenes / chemistry,  metabolism
Plants / genetics*,  metabolism*
Grant Support
ID/Acronym/Agency:
BB/J004561/1//Biotechnology and Biological Sciences Research Council; GM074820/GM/NIGMS NIH HHS; R01 GM074820/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Benzylisoquinolines; 0/Biological Products; 0/Glucosinolates; 0/Indole Alkaloids; 0/Monoterpenes; 9035-51-2/Cytochrome P-450 Enzyme System
Comments/Corrections

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