| Recent progress in the metabolic engineering of alkaloids in plant systems. | |
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MedLine Citation:
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PMID: 22954587 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Plant alkaloids have a rich chemical ecology that has been exploited for medicinal purposes for thousands of years. Despite being highly represented within today's pharmacopoeia, relatively little is known about the biosynthesis, regulation and transport of these molecules. Understanding how nature synthesizes plant alkaloids will enhance our ability to overproduce-that is, to metabolically engineer-these medicinally useful compounds as well as new-to-nature compounds (with potentially improved bioactivity) derived from these natural scaffolds. Recent progress in the metabolic engineering of nitrogen-containing plant natural products-specifically the monoterpene indole alkaloids, the benzylisoquinoline alkaloids and the glucosinolates-was made possible through the characterization of various components in both native and engineered enzymatic pathways. The subsequent reconfiguration and tuning of these biological 'parts' has enabled the production of selected products at increasingly higher titers. |
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Authors:
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Weslee S Glenn; Weerawat Runguphan; Sarah E O'Connor |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-3 |
Journal Detail:
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Title: Current opinion in biotechnology Volume: - ISSN: 1879-0429 ISO Abbreviation: Curr. Opin. Biotechnol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100492 Medline TA: Curr Opin Biotechnol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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John Innes Centre, Department of Biological Chemistry, Norwich Research Park, Norwich NR4 7UH, UK; Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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