| Recent progress in chemical and chemoenzymatic synthesis of carbohydrates. | |
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MedLine Citation:
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PMID: 19833544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The important roles that carbohydrates play in biological processes and their potential application in diagnosis, therapeutics, and vaccine development have made them attractive synthetic targets. Despite ongoing challenges, tremendous progresses have been made in recent years for the synthesis of carbohydrates. The chemical glycosylation methods have become more sophisticated and the synthesis of oligosaccharides has become more predictable. Simplified one-pot glycosylation strategy and automated synthesis are increasingly used to obtain biologically important glycans. On the other hand, chemoenzymatic synthesis continues to be a powerful alternative for obtaining complex carbohydrates. This review highlights recent progress in chemical and chemoenzymatic synthesis of carbohydrates with a particular focus on the methods developed for the synthesis of oligosaccharides, polysaccharides, glycolipids, and glycosylated natural products. |
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Authors:
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Saddam Muthana; Hongzhi Cao; Xi Chen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2009-10-14 |
Journal Detail:
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Title: Current opinion in chemical biology Volume: 13 ISSN: 1879-0402 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-02 Completed Date: 2010-01-29 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: England |
Other Details:
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Languages: eng Pagination: 573-81 Citation Subset: IM |
Affiliation:
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Department of Chemistry, One Shields Avenue, University of California, Davis, CA 95616, United States. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Products
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biosynthesis,
chemical synthesis Carbohydrates / biosynthesis*, chemical synthesis* Enzymes / metabolism* Glycolipids / biosynthesis, chemical synthesis Glycoside Hydrolases / metabolism Glycosylation Humans Polysaccharides / biosynthesis, chemical synthesis |
| Grant Support | |
ID/Acronym/Agency:
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GM076360/GM/NIGMS NIH HHS; R01 GM076360-04/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Carbohydrates; 0/Enzymes; 0/Glycolipids; 0/Polysaccharides; EC 3.2.1.-/Glycoside Hydrolases |
| Comments/Corrections | |
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