| Recent progress on an endogenous digitalislike factor in hypertension. | |
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MedLine Citation:
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PMID: 3020179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence exists that demonstrates the relationship between a natriuretic factor, or Na+, K+-ATPase inhibitor, and volume expansion in man. Patients having extracellular volume expansion have been studied for the effect of their plasma on erythrocyte [3H]ouabain binding. High levels of ouabainlike activity were found in plasma from acromegalic patients and patients with chronic renal failure. High levels were also observed in some hypertensive patients. A partial purification of such a compound was performed from the urine of hypertensive patients. The various steps of purification achieved a 400,000-fold purified compound of apparent homogeneity. The inhibitor was extracted from 140 liters of urine of 21 donors (hypertensive patients and normotensive offspring of hypertensive patients). The purification steps included flash chromatography, anionic exchange, and reversed-phase HPLC on RP 18, diphenyl and phenyl packings. Nuclear magnetic resonance and mass spectrometry indicated a nonpeptidic compound, which was possibly a steroid with a low molecular mass (less than 500 daltons). |
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Authors:
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J F Cloix; M Crabos; P Meyer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical hypertension Volume: 2 ISSN: 0748-450X ISO Abbreviation: J Clin Hypertens Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-11-07 Completed Date: 1986-11-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8510461 Medline TA: J Clin Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 93-100 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Binding, Competitive Blood Proteins / isolation & purification, pharmacology, physiology* Cardenolides Digoxin* Dose-Response Relationship, Drug Erythrocytes / ultrastructure Female Homeostasis Humans Hypertension / blood, metabolism, physiopathology* Male Middle Aged Ouabain / metabolism Saponins* Sodium / physiology Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Cardenolides; 0/Saponins; 0/digoxin-like factors; 20830-75-5/Digoxin; 630-60-4/Ouabain; 7440-23-5/Sodium; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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