| Recent perspectives on the toxicodynamic basis of cyanide antagonism. | |
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MedLine Citation:
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PMID: 6327443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanism of action of nitrite-thiosulfate (Chen et al., 1933a ,b; Hug , 1933) in the antagonism of the lethal effects of cyanide is much more complex than proposed 50 years ago. Some of the recent findings concerning the mechanism of nitrite action have conceptual theoretical and practical significance, as the development of newer cyanide antagonists are dependent on the elucidation of the basic mechanism of antidotal action. There are preliminary evidence which suggest a vasogenic action rather than methemoglobin formation is the primary action of nitrite, as a cyanide antagonist. Various vasogenic compounds have been uncovered and they may play an important role in the future development of a new class of cyanide antagonists. Also recent development in thiol detoxication of cyanide suggest that rhodanese may play a more complex role. The detoxification of cyanide may be viewed from a considerably more complex perspective with the elucidation of recent mechanisms. It also may provide a newer conceptual basis for a more rational development of future compounds to antagonize the lethal effects of cyanide. |
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Authors:
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J L Way; D Sylvester; R L Morgan; G E Isom; G E Burrows; C B Tamulinas; J L Way |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Fundamental and applied toxicology : official journal of the Society of Toxicology Volume: 4 ISSN: 0272-0590 ISO Abbreviation: Fundam Appl Toxicol Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-07-09 Completed Date: 1984-07-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200838 Medline TA: Fundam Appl Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S231-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antidotes / pharmacology* Cobalt / pharmacology Cyanides / antagonists & inhibitors*, toxicity Electron Transport Complex IV / metabolism Humans Methemoglobin / biosynthesis Oxygen / pharmacology Oxygen Consumption / drug effects Schiff Bases / metabolism Sulfhydryl Compounds / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antidotes; 0/Cyanides; 0/Schiff Bases; 0/Sulfhydryl Compounds; 7440-48-4/Cobalt; 7782-44-7/Oxygen; 9008-37-1/Methemoglobin; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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