Document Detail


Recent insights into the pathophysiology of preeclampsia.
MedLine Citation:
PMID:  21170149     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Preeclampsia, characterized by new-onset gestational hypertension and proteinuria, is a common and serious complication of pregnancy. Evidence from both animal and human studies has implicated placental ischemia and hypoxia as a central causative factor in the etiology of the disorder. The ischemic placenta in turn initiates a cascade of secondary effector mechanisms, including altered proangiogenic and antiangiogenic factor balance, increase in maternal oxidative stress and endothelial and immunological dysfunction. The full elucidation of these mechanisms will hopefully lead to a more complete understanding of the etiology of preeclampsia and lead to successful therapeutic intervention through the targeted disruption of new and novel pathways.
Authors:
Eric M George; Joey P Granger
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Expert review of obstetrics & gynecology     Volume:  5     ISSN:  1747-4116     ISO Abbreviation:  -     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278194     Medline TA:  Expert Rev Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  557-566     Citation Subset:  -    
Affiliation:
Department of Physiology and Biophysics and the Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USA.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P01 HL051971-16//NHLBI NIH HHS

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