| Recent insights into the pathogenesis and therapeutics of pulmonary hypertension. | |
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MedLine Citation:
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PMID: 11869166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The normal adult pulmonary circulation is a low-pressure, high-capacity circuit. Pulmonary vascular resistance is regulated by alveolar oxygen tension, potassium channels and a variety of locally produced and circulating vasoactive factors. Perturbations of these systems may contribute to the pathogenesis of pulmonary hypertension. Recently, mutations in BMPR2 and ALK-1, genes that encode members of the transforming growth factor-beta (TGF-beta) receptor superfamily, have been found in patients with primary pulmonary hypertension. These observations provide a novel insight into the pathogenesis of primary pulmonary hypertension, and emphasize the importance of the integrity of the TGF-beta receptor family in the maintenance of normal pulmonary vascular structure and function. This review discusses the latest developments in the field of pulmonary vascular biology and the prospects for improving the treatment of pulmonary hypertension. |
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Authors:
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Julian W Strange; John Wharton; Peter G Phillips; Martin R Wilkins |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 102 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-02-28 Completed Date: 2002-03-25 Revised Date: 2012-06-25 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 253-68 Citation Subset: IM |
Affiliation:
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Section on Clinical Pharmacology, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / complications Bone Morphogenetic Protein Receptors, Type II Female Gene Therapy Humans Hypertension, Pulmonary / etiology*, therapy* Male Mutation Potassium Channels / metabolism Protein-Serine-Threonine Kinases / genetics Pulmonary Artery / pathology Pulmonary Disease, Chronic Obstructive / complications Vascular Resistance Vasodilator Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels; 0/Vasodilator Agents; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.11.30/BMPR2 protein, human; EC 2.7.11.30/Bone Morphogenetic Protein Receptors, Type II |
| Comments/Corrections | |
Comment In:
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Clin Sci (Lond). 2002 Oct;103(4):345; author reply 346
[PMID:
12241531
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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