| Recent insights into microbial triggers of interleukin-10 production in the host and the impact on infectious disease pathogenesis. | |
| | |
MedLine Citation:
|
PMID: 22268692 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Since its initial description as a Th2-cytokine antagonistic to interferon-alpha and granulocyte macrophage-colony stimulating factor, many studies have shown various anti-inflammatory actions of interleukin-10 (IL-10), and its role in infection as a key regulator of innate immunity. Studies have shown that IL-10 induced in response to microbes and their products plays a central role in shaping pathogenesis. IL-10 appears to function as both sword and shield in the response to varied groups of microbes in its capacity to mediate protective immunity against some organisms but increase susceptibility to other infections. The nature of IL-10 as a pleiotropic modulator of host responses to microbes is explained, in part, by its potent and varied effects on different immune effector cells which influences antimicrobial activity. A new understanding of how microbes trigger IL-10 responses is emerging, along with recent discoveries of how IL-10 produced during disease might be harnessed for better protective or therapeutic strategies. In this review, we summarize studies from the past five years that have reported the induction of IL-10 by different classes of pathogenic microbes including protozoa, nematodes, fungi, viruses and bacteria, and discuss the impact of this induction on the persistence and/or clearance of microbes in the host. |
| | |
Authors:
|
Benjamin L Duell; Chee K Tan; Alison J Carey; Fan Wu; Allan W Cripps; Glen C Ulett |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-23 |
Journal Detail:
|
Title: FEMS immunology and medical microbiology Volume: - ISSN: 1574-695X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9315554 Medline TA: FEMS Immunol Med Microbiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved. |
Affiliation:
|
School of Medical Sciences, Centre for Medicine and Oral Health, Griffith University Gold Coast Campus, QLD, Australia, 4222. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative and meta-analytic insights into life-extension via dietary restriction.
Next Document: Genotype?×?environment interaction, environmental heterogeneity and the lek paradox.