| Recent findings on the viable but nonculturable state in pathogenic bacteria. | |
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MedLine Citation:
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PMID: 20059548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many bacteria, including a variety of important human pathogens, are known to respond to various environmental stresses by entry into a novel physiological state, where the cells remain viable, but are no longer culturable on standard laboratory media. On resuscitation from this 'viable but nonculturable' (VBNC) state, the cells regain culturability and the renewed ability to cause infection. It is likely that the VBNC state is a survival strategy, although several interesting alternative explanations have been suggested. This review describes the VBNC state, the various chemical and physical factors known to induce cells into this state, the cellular traits and gene expression exhibited by VBNC cells, their antibiotic resistance, retention of virulence and ability to attach and persist in the environment, and factors that have been found to allow resuscitation of VBNC cells. Along with simple reversal of the inducing stresses, a variety of interesting chemical and biological factors have been shown to allow resuscitation, including extracellular resuscitation-promoting proteins, a novel quorum-sensing system (AI-3) and interactions with amoeba. Finally, the central role of catalase in the VBNC response of some bacteria, including its genetic regulation, is described. |
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Authors:
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James D Oliver |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2009-11-24 |
Journal Detail:
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Title: FEMS microbiology reviews Volume: 34 ISSN: 1574-6976 ISO Abbreviation: FEMS Microbiol. Rev. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902526 Medline TA: FEMS Microbiol Rev Country: England |
Other Details:
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Languages: eng Pagination: 415-25 Citation Subset: IM |
Affiliation:
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Department of Biology, University of North Carolina at Charlotte, Charlotte, NC, USA. jdoliver@uncc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria / growth & development, isolation & purification*, pathogenicity* Bacterial Adhesion Bacterial Infections / microbiology* Bacterial Physiological Phenomena* Bacterial Proteins / metabolism Catalase / metabolism Drug Resistance, Bacterial Gene Expression Profiling Gene Expression Regulation, Bacterial Humans Microbial Viability* Quorum Sensing |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; EC 1.11.1.6/Catalase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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