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Recent findings in the epidemiology, diagnosis and treatment of superficial-vein thrombosis.
MedLine Citation:
PMID:  21262449     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent data on lower-limb superficial-vein thrombosis (SVT) may substantially impact its clinical management. Thus, the clear confirmation that SVT is closely linked to deep-vein thrombosis (DVT) or pulmonary embolism (PE) highlights the potential severity of the disease. DVT or PE are diagnosed in 20-30% of SVT patients. Moreover, clinically relevant symptomatic thromboembolic events complicate isolated SVT (without concomitant DVT or PE at diagnosis) in 4-8% of patients. For the first time, an anticoagulant treatment, once-daily 2.5 mg fondaparinux for 45 days, was demonstrated to be effective and safe for preventing these symptomatic thromboembolic events in patients with lower-limb isolated SVT in the randomized placebo-controlled CALISTO study. Based on these recent findings, new recommendations on the management of SVT patients, including complete ultrasonography examination of the legs, and in patients with isolated SVT, prescription of once-daily 2.5 mg fondaparinux subcutaneously for 45 days on top of symptomatic treatments, may be proposed.
Authors:
Hervé Décousus; Laurent Bertoletti; Paul Frappé; François Becker; Asma El Jaouhari; Patrick Mismetti; Nathalie Moulin; Emilie Presles; Isabelle Quéré; Alain Leizorovicz
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Thrombosis research     Volume:  127S3     ISSN:  1879-2472     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  S81-S85     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
INSERM, CIE3; Université Jean Monnet, EA3065; CHU Saint-Etienne, Service de Médecine et Thérapeutique, Saint-Etienne, F-42055 France.
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