Document Detail


Recent environmental toxic effect in the Polish copper mining territory on human reproduction. Part I. Response of the placenta to the chemical stress.
MedLine Citation:
PMID:  15303375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined morphochemical differences between 49 full term human placentas collected from healthy non-smoking women living in the high polluted region, i.e. the Copper Mining Territory (CMT) and the 38 control placentas (C) obtained from little polluted eastern Carpathian regions. The placentas were studied by histochemical, immunohistochemical and morphometric methods. In CMT placentas a decrease in the cytochrome c oxidase and glucose-6-phosphate activities and the immunoreactivity of glutathione S-transferase pi in the villous syncytiotrophoblast and amniotic epithelium was noted. All CMT placentas showed abundance of mineral and fibrinoid deposits and of lipid droplets. This produced a compensatory increase in the mother-fetus exchange area due to excessive proliferation of placental villi which in turn decreased the intervillous space and thus the influx of indispensable maternal blood. Lately slight signs of increase in the cytochrome c oxidase activity accompanied by a noticeable decrease in number of the thinnest (most abundant) terminal villi is observed.
Authors:
Monika Zadrozna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia biologica     Volume:  51     ISSN:  0015-5497     ISO Abbreviation:  Folia Biol. (Krakow)     Publication Date:  2003  
Date Detail:
Created Date:  2004-08-11     Completed Date:  2004-08-24     Revised Date:  2006-12-14    
Medline Journal Info:
Nlm Unique ID:  2984758R     Medline TA:  Folia Biol (Krakow)     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  201-5     Citation Subset:  IM    
Affiliation:
Department of Cytobiology and Histochemistry, Collegium Medicum, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland. monika.zadrozna@wp.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Chorionic Villi / drug effects,  pathology
Copper / poisoning*
Electron Transport Complex IV / analysis,  pharmacology*
Environmental Exposure*
Female
Glutathione Transferase / analysis,  pharmacology
Humans
Immunohistochemistry
Lipids / analysis
Maternal-Fetal Exchange / drug effects*,  physiology
Mining
Placenta / drug effects*,  pathology,  physiology*
Poland
Pregnancy
Chemical
Reg. No./Substance:
0/Lipids; 7440-50-8/Copper; EC 1.9.3.1/Electron Transport Complex IV; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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