Document Detail

Recent developments on lipolysis regulation in humans and discovery of a new lipolytic pathway.
MedLine Citation:
PMID:  11126242     Owner:  NLM     Status:  MEDLINE    
In man, the major hormones controlling the lipolytic function are insulin (inhibition of lipolysis) and catecholamines (stimulation of lipolysis). Catecholamines are of major importance for the regulation of lipid mobilization in human adipose tissue and for the increase of non-esterified fatty acid supply to the working muscle. In vitro studies have shown that there are differences in the catecholaminergic control of fat cells from various fat deposits and a number of physiological and pathological alterations of catecholamine-induced lipolysis have been reported. Lipolytic resistance to catecholamines has been reported in subcutaneous adipose tissue, the major fat depot in obese subjects. Multiple alterations in catecholamine signal transduction pathways have been reported. In situ microdialysis allows a physiological exploration of adipose tissue biology. Recent data obtained on the catecholaminergic regulation of lipolysis and lipid mobilization, using microdialysis in humans, will be analysed. A potent lipolytic and lipomobilizing effect of atrial natriuretic peptide has recently been discovered; the mechanisms of action and physiological relevance will also be discussed.
M Lafontan; C Sengenes; J Galitzky; M Berlan; I De Glisezinski; F Crampes; V Stich; D Langin; P Barbe; D Rivière
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity     Volume:  24 Suppl 4     ISSN:  -     ISO Abbreviation:  Int. J. Obes. Relat. Metab. Disord.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-03-15     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  9313169     Medline TA:  Int J Obes Relat Metab Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  S47-52     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / metabolism*
Atrial Natriuretic Factor / physiology
Catecholamines / physiology*
Receptors, Adrenergic / physiology*
Sterol Esterase / metabolism*
Reg. No./Substance:
0/Catecholamines; 0/Receptors, Adrenergic; 85637-73-6/Atrial Natriuretic Factor; EC Esterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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