Document Detail


Recent developments in the treatment of uveitis: an update.
MedLine Citation:
PMID:  19388878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The management of complex uveitis is often based around the use of oral corticosteroids. To spare the side effects of corticosteroids, second-line oral immunosuppressant drugs are used. Newer systemic immunosuppressive drugs, including biologics, and locally delivered treatments are being evaluated. This article reviews current conventional treatments, discusses their limitations and evaluates newer treatment strategies. Current theories about the pathogenesis of uveitis and potential targets for treatment are discussed in this context. We are still in search of a low-risk, where possible, locally delivered and targeted treatment for uveitis.
Authors:
Fiona Lyon; Richard P Gale; Susan Lightman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  18     ISSN:  1744-7658     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-24     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  609-16     Citation Subset:  IM    
Affiliation:
Academic Unit of Ophthalmology, York Hospital, Wigginton Road, York YO318HE, UK.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Animals
Drug Discovery / methods,  trends*
Humans
Immunosuppressive Agents / therapeutic use
Treatment Outcome
Uveitis / drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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