Document Detail

Recent developments in meta-analysis.
MedLine Citation:
PMID:  17590884     Owner:  NLM     Status:  MEDLINE    
The art and science of meta-analysis, the combination of results from multiple independent studies, is now more than a century old. In the last 30 years, however, as the need for medical research and clinical practice to be based on the totality of relevant and sound evidence has been increasingly recognized, the impact of meta-analysis has grown enormously. In this paper, we review highlights of recent developments in meta-analysis in medical research. We outline in particular how emphasis has been placed on (i) heterogeneity and random-effects analyses; (ii) special consideration in different areas of application; (iii) assessing bias within and across studies; and (iv) extension of ideas to complex evidence synthesis. We conclude the paper with some remarks on ongoing challenges and possible directions for the future.
Alexander J Sutton; Julian P T Higgins
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Statistics in medicine     Volume:  27     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-06-17     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  625-50     Citation Subset:  IM    
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MeSH Terms
Biomedical Research / statistics & numerical data*
Meta-Analysis as Topic*
Statistics as Topic / methods
Grant Support
MC_U105285807//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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