Document Detail

Recent developments in the histological diagnosis of spindle cell carcinoma, fibromatosis and phyllodes tumour of the breast.
MedLine Citation:
PMID:  18171416     Owner:  NLM     Status:  MEDLINE    
This article reviews recent advances in the diagnosis of these three unusual tumours of the breast. Spindle cell carcinoma needs to be considered in the differential diagnosis of many mammary spindle cell lesions: it is important to be aware of the wide range of appearances, including the recently described fibromatosis-like variant. Immunohistochemistry using a broad panel of cytokeratin antibodies is needed to exclude spindle cell carcinoma; there is frequent expression of basal cytokeratins and p63. CD34 is often expressed by the stroma of phyllodes tumours, but does not appear to be expressed by spindle cell carcinoma or fibromatosis. Nuclear beta-catenin is found in about 80% of fibromatoses, but can also be seen in spindle cell carcinomas and phyllodes tumours. Two recent studies have described features useful in the distinction of phyllodes tumour and fibroadenoma on core biopsy, including increased cellularity, mitoses and overgrowth of the stroma, adipose tissue in the stroma and fragmentation of the biopsy specimen. Periductal stromal tumour is a recently described biphasic tumour composed of spindle cells around open tubules or ducts (but no leaf-like architecture) with frequent CD34 expression. The overlap of morphology with phyllodes tumour suggests that it may be best regarded as a variant of phyllodes tumour.
A H S Lee
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Histopathology     Volume:  52     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-03     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  45-57     Citation Subset:  IM    
Histopathology Department, Nottingham University Hospitals, City Hospital Campus, Nottingham, UK.
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MeSH Terms
Antigens, CD34 / metabolism
Breast Neoplasms / diagnosis,  metabolism,  pathology*
Carcinoma / diagnosis,  metabolism,  pathology*
Diagnosis, Differential
Fibroma / diagnosis,  metabolism,  pathology*
Phyllodes Tumor / diagnosis,  metabolism,  pathology*
Reg. No./Substance:
0/Antigens, CD34

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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