| Recent developments in allene-based synthetic methods. | |
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MedLine Citation:
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PMID: 18946849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Presented is a review of the advances in synthetic methodology that make use of the allene functional group, with emphasis on catalytic asymmetric transformations and new mechanistic insights. The review covers the period from January 2007 to May 2008 and focuses on intra- and intermolecular cycloaddition, carbocycle cycloisomerization, heterocycle synthesis, epoxidation, addition and miscellaneous transformations. A brief discussion of allenes as transition metal ligands, the use of allenes in total synthesis and potential medicinal agents that contain the allene functionality is also presented. |
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Authors:
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Hiyun Kim; Lawrence J Williams |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in drug discovery & development Volume: 11 ISSN: 1367-6733 ISO Abbreviation: Curr Opin Drug Discov Devel Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-23 Completed Date: 2008-11-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100887519 Medline TA: Curr Opin Drug Discov Devel Country: England |
Other Details:
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Languages: eng Pagination: 870-94 Citation Subset: IM |
Affiliation:
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Rutgers, The State University of New Jersey, Department of Chemistry and Chemical Biology, Piscataway, NJ 08854, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkadienes
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chemistry* Chemistry, Pharmaceutical* Free Radicals / chemistry Heterocyclic Compounds / chemical synthesis Pharmaceutical Preparations / chemical synthesis* |
| Chemical | |
Reg. No./Substance:
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0/Alkadienes; 0/Free Radicals; 0/Heterocyclic Compounds; 0/Pharmaceutical Preparations; 463-49-0/propadiene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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