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Recent development in [1,4]benzodiazepines as potent anticancer agents: a review.
MedLine Citation:
PMID:  25311001     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The [1,4]benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]benzodiazepine from CNS acting drugs to anticancer agents. During last few decades, a large number of reports have appeared in the literature highlighting the anticancer activity of [1,4]benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]benzodiazepines as anticancer agent, their mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades till date.
Authors:
Rupinder Kaur Gill; Shiv Om Kaushik; Jasreen Chugh; Sumit Bansal; Anamik Shah; Jitender Bariwal
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  14     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  229-56     Citation Subset:  IM    
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