Document Detail

Recent development in [1,4]-Benzodiazepines as Potent Anticancer Agents: A Review.
MedLine Citation:
PMID:  24001335     Owner:  NLM     Status:  Publisher    
The [1,4]-benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]-benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]-benzodiazepine from CNS acting drugs to anticancer agent. During last few decades, large number of reports has appeared in the literature highlighting the anticancer activity of [1,4]-benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]-benzodiazepines as anticancer agent, its mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades to till date.
Rupinder Kaur Gilla; Shiv Om Kaushika; Jasreen Chugha; Sumit Bansalb; Anamik Shahc; Jitender Bariwala
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-02
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  -     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga-142001, Punjab, India.
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