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Recent development in [1,4]-Benzodiazepines as Potent Anticancer Agents: A Review.
MedLine Citation:
PMID:  24001335     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The [1,4]-benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]-benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]-benzodiazepine from CNS acting drugs to anticancer agent. During last few decades, large number of reports has appeared in the literature highlighting the anticancer activity of [1,4]-benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]-benzodiazepines as anticancer agent, its mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades to till date.
Authors:
Rupinder Kaur Gilla; Shiv Om Kaushika; Jasreen Chugha; Sumit Bansalb; Anamik Shahc; Jitender Bariwala
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-02
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  -     ISSN:  1875-5607     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga-142001, Punjab, India. jitender.bariwal@gmail.com.
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