Document Detail


Recent applications of enzymatic peptide synthesis.
MedLine Citation:
PMID:  8015977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent applications of enzyme catalysis in peptide synthesis are reviewed. A brief history of the development of these techniques is presented, and existing strategies and tactics of regio- and stereospecific peptide bond syntheses catalyzed by proteolytic enzymes are summarized. The recent literature (ca. 1987-1992) is surveyed for selected applications of enzyme catalysis to the synthesis of bioactive peptides and analogues, semisynthetic proteins and protein conjugates, and bioactive peptides from recombinant precursors. Newly isolated natural enzymes as well as chemically modified forms and recombinant mutants of the natural enzymes of potential utility in peptide synthesis are also reviewed.
Authors:
J Bongers; E P Heimer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Peptides     Volume:  15     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-07-26     Completed Date:  1994-07-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  183-93     Citation Subset:  IM    
Affiliation:
Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Catalysis
Endopeptidases / chemistry,  classification
Enzymes / metabolism*
Kinetics
Molecular Sequence Data
Peptide Biosynthesis*
Thermodynamics
Chemical
Reg. No./Substance:
0/Enzymes; EC 3.4.-/Endopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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