Document Detail

Recent advances on stearoyl-CoA desaturase regulation in fatty liver diseases.
MedLine Citation:
PMID:  22978399     Owner:  NLM     Status:  Publisher    
Stearoyl-CoA desaturase 1 (SCD-1) is a delta-9 fatty acid desaturase that catalyzes the synthesis of monounsaturated fatty acids. Indeed, SCD-1 is the critical control point regulating hepatic lipogenesis and lipid oxidation. Due to its central role in lipid metabolism in the liver, recent studies have focused on the involvement of SCD-1 in the development of fatty liver during obesity, diabetes mellitus, hypertension, excessive alcohol consumption, and in subjects with high triglyceride blood concentrations. The accumulation of fat in liver cells can be a sign that harmful conditions are developing, possibly associated with or leading to inflammation of the liver. This review evaluates the recent advances in our understanding of the regulation of SCD-1 expression and its role in the development of nonalcoholic and alcoholic hepatosteatosis. Animal models presenting a liver-specific loss or inhibition of SCD-1, as well as dietary interventions, have highlighted the important role of the enzyme in the accumulation of fat (fatty infiltration) in hepatocytes during both alcoholic and nonalcoholic liver diseases. The data summarized in this article support the notion that SCD-1 plays a direct role in the development of fatty liver diseases, and is not simply a marker of an unfavorable diet or hepatic disorder. Accordingly, SCD-1 represents a promising therapeutic target for the treatment of hepatic steatosis.
Michel Narce; Jérôme Bellenger; Mickaël Rialland; Sandrine Bellenger
Related Documents :
7682889 - Transduction mechanisms in the olfactory and vomeronasal organs of turtles.
11126869 - Resolution of racemic albuterol via diastereomeric salts formation with di-p-toluoyl-d-...
15479089 - Crystal engineering approach to forming cocrystals of amine hydrochlorides with organic...
5903089 - Repair of thermal injury of staphylococcus aureus.
6181179 - Bleomycin compatibility with selected intravenous medications.
23141889 - Primary sclerosing cholangitis and bile acids.
19079939 - Leptin regulation of lipid homeostasis: dietary and metabolic implications.
1203259 - Elongation factor 2 as the target of the reaction product between sodium selenite and g...
11534459 - Species/variety differences in biochemical composition and nutritional value of indian ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-04
Journal Detail:
Title:  Current drug metabolism     Volume:  -     ISSN:  1875-5453     ISO Abbreviation:  Curr. Drug Metab.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960533     Medline TA:  Curr Drug Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
INSERM, UMR 866, Lipides Nutrition Cancer, Université de Bourgogne, 6 Bd Gabriel, 21000 Dijon, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  PPAR?/HNF4? interplay on diversified responsive elements. Relevance in the regulation of liver perox...
Next Document:  MC1R variants predisposing to concomitant primary cutaneous melanoma in a monozygotic twin pair.