| Recent advances in understanding the relationship between adenosine metabolism and the function of T and B lymphocytes in diabetes. | |
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MedLine Citation:
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PMID: 22204797 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Adenosine plays an important role in physiology of several organs. Its turnover inside and outside of the cell is controlled by several enzymes and transport processes. The action of extracellular adenosine is mediated via at least four receptors named A(1), A(2A), A(2B), and A(3). Recent studies have reported that adenosine is a significant mediator of regulatory lymphocyte function. Numerous data indicates that adenosine affects T lymphocyte activation, proliferation and lymphocyte-mediated cytolysis. Impaired lymphocyte functioning and enhanced susceptibility to infections is a common feature of human diabetes. This review collects data bringing us closer to understanding the disturbances in lymphocytes adenosine homeostasis in diabetes. Adenosine receptors and nucleoside transporters are targets for potential drugs in many pathophysiological situations. Therefore, action of adenosine on lymphocyte function in diabetes may be important target for modulation of immune responses and understanding of mechanisms leading to several pathologies of immune cells observed in diabetes. |
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Authors:
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M Sakowicz-Burkiewicz; T Pawelczyk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 62 ISSN: 1899-1505 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-12-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 505-12 Citation Subset: IM |
Affiliation:
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Department of Molecular Medicine, Medical University of Gdansk, Poland. ssak@gumed.edu.pl. |
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