Document Detail

Recent advances in understanding of preeclampsia.
MedLine Citation:
PMID:  16158464     Owner:  NLM     Status:  MEDLINE    
Despite intensive research, preeclampsia still accounts for significant morbidity and mortality for the mother and the neonate, especially in developing countries. Recent studies have suggested that excess secretion of a naturally occurring anti-angiogenic molecule of placental origin referred to as soluble fms-like tyrosine kinase-1 (sFlt-1, also referred to as sVEGFR-1) may contribute to the pathogenesis of preeclampsia. sFlt-1 acts by antagonizing two pro-angiogenic molecules - vascular endothelial growth factor (VEGF) and placental growth factor (PlGF). Abnormalities in the angiogenic balance have been proposed as having a major role in the molecular cascade leading to proteinuria, hypertension, and endothelial dysfunction. Further evidence supports the hypothesis that angiogenic balance is crucial to differentiation and invasion of cytotrophoblasts. The abnormal placentation and the accompanying hypoxia may, in turn, result in more sFlt-1 production, thus leading to a vicious cycle of sFlt-1 production, eventually causing preeclampsia. These recent discoveries may facilitate the development of novel strategies for the diagnosis and therapy of preeclampsia.
Yuval Bdolah; S Ananth Karumanchi; Benjamin P Sachs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Croatian medical journal     Volume:  46     ISSN:  0353-9504     ISO Abbreviation:  Croat. Med. J.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-12-14     Revised Date:  2009-11-25    
Medline Journal Info:
Nlm Unique ID:  9424324     Medline TA:  Croat Med J     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  728-36     Citation Subset:  IM    
Department of Obstetrics and Gynecology and Reproductive Sciences, Beth Israel Deaconess Medical Center, 330 Brookline Avenue-KS3182, Boston, MA 02215, USA.
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MeSH Terms
Neovascularization, Physiologic
Pre-Eclampsia / physiopathology*
Pregnancy Proteins*
Vascular Endothelial Growth Factor A*
Reg. No./Substance:
0/Pregnancy Proteins; 0/Vascular Endothelial Growth Factor A; 144589-93-5/placenta growth factor

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