Document Detail

Recent advances in understanding of preeclampsia.
MedLine Citation:
PMID:  16158464     Owner:  NLM     Status:  MEDLINE    
Despite intensive research, preeclampsia still accounts for significant morbidity and mortality for the mother and the neonate, especially in developing countries. Recent studies have suggested that excess secretion of a naturally occurring anti-angiogenic molecule of placental origin referred to as soluble fms-like tyrosine kinase-1 (sFlt-1, also referred to as sVEGFR-1) may contribute to the pathogenesis of preeclampsia. sFlt-1 acts by antagonizing two pro-angiogenic molecules - vascular endothelial growth factor (VEGF) and placental growth factor (PlGF). Abnormalities in the angiogenic balance have been proposed as having a major role in the molecular cascade leading to proteinuria, hypertension, and endothelial dysfunction. Further evidence supports the hypothesis that angiogenic balance is crucial to differentiation and invasion of cytotrophoblasts. The abnormal placentation and the accompanying hypoxia may, in turn, result in more sFlt-1 production, thus leading to a vicious cycle of sFlt-1 production, eventually causing preeclampsia. These recent discoveries may facilitate the development of novel strategies for the diagnosis and therapy of preeclampsia.
Yuval Bdolah; S Ananth Karumanchi; Benjamin P Sachs
Related Documents :
16014444 - Growth regulation of the vascular system: an emerging role for adenosine.
21031024 - A novel antiangiogenic peptide derived from hepatocyte growth factor inhibits neovascul...
19109954 - Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome.
19800534 - Introduction: understanding the role of angiogenesis and antiangiogenic agents in age-r...
7657514 - Plasmin in pericellular proteolysis and cellular invasion.
8430854 - Endothelium increases medial hydraulic conductance of aorta, possibly by release of edrf.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Croatian medical journal     Volume:  46     ISSN:  0353-9504     ISO Abbreviation:  Croat. Med. J.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-12-14     Revised Date:  2009-11-25    
Medline Journal Info:
Nlm Unique ID:  9424324     Medline TA:  Croat Med J     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  728-36     Citation Subset:  IM    
Department of Obstetrics and Gynecology and Reproductive Sciences, Beth Israel Deaconess Medical Center, 330 Brookline Avenue-KS3182, Boston, MA 02215, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Neovascularization, Physiologic
Pre-Eclampsia / physiopathology*
Pregnancy Proteins*
Vascular Endothelial Growth Factor A*
Reg. No./Substance:
0/Pregnancy Proteins; 0/Vascular Endothelial Growth Factor A; 144589-93-5/placenta growth factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ethics and growing legal crisis in medicine.
Next Document:  Extrauterine growth restriction in preterm infants: importance of optimizing nutrition in neonatal i...