Document Detail


Recent advances in understanding molecular mechanisms in the pathogenesis and antibody profile of Sjögren's syndrome.
MedLine Citation:
PMID:  14531959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sjögren's syndrome is a chronic autoimmune and rheumatic disorder of the mucous membranes caused by a lack of proper exocrine secretions, with prominent sicca complaints. The molecular mechanisms of the pathogenesis are virtually unknown, although progress has been made with regard to chemokines, B cell activating factor, and apoptosis. A large number of autoantibodies have been reported in Sjögren's syndrome, some of which relate to impairment of glandular function. Sjögren's syndrome is a female-dominant disease with a late age of onset; most patients contract the disease at the age of 40 to 50 years. Lately, attention has been drawn to the effects of adrenopause in Sjögren's syndrome and on dehydroepiandrosterone and its intracrine metabolism in target tissues. This can influence the maintenance and remodeling of exocrine glands and may explain, in part, another important disease symptom--fatigue.
Authors:
Roland Jonsson; Tom P Gordon; Yrjö T Konttinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current rheumatology reports     Volume:  5     ISSN:  1523-3774     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-10-08     Completed Date:  2004-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-6     Citation Subset:  IM    
Affiliation:
Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Armauer Hansen Building, NO-5021 Bergen, Norway. roland.jonsson@gades.uib.no
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Apoptosis / immunology
Aquaporins / metabolism
Autoantibodies / metabolism
Autoimmune Diseases / immunology,  physiopathology*
B-Lymphocytes / immunology
Female
Humans
Rheumatic Diseases / immunology,  physiopathology*
Sjogren's Syndrome* / drug therapy,  immunology,  physiopathology
Synaptic Transmission / immunology
Chemical
Reg. No./Substance:
0/Aquaporins; 0/Autoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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