| Recent advances in preventing cardiovascular disorders by managing lipid levels. | |
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MedLine Citation:
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PMID: 21173859 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Advances in clinical lipidology during the last 18 months include the establishment of high-sensitivity C-reactive protein (hsCRP) as an important risk marker for cardiovascular disease. Determining hsCRP levels should help the clinician single out patients at particularly high risk. However, more research needs to be done in this area. Furthermore, statins do not seem to be of benefit in patients with severe congestive heart failure, on chronic hemodialysis, or with aortic stenosis. Next, plasma triglyceride levels are now considered an important risk marker for cardiovascular disease, but the therapeutic benefits related to lowering triglyceride levels remain difficult to achieve. Also, nicotinic acid has gained more interest partly because recent studies have demonstrated positive effects on atherosclerosis development and partly because the side effect of flushing seems to be partially avoidable with the concomitant administration of laropiprant. Both the raising of high-density lipoprotein cholesterol by nicotinic acid and the additional lowering of low-density lipoprotein cholesterol by ezetimibe and eprotirome will need to demonstrate hard endpoint reductions in large-scale intervention trials. Trials of niacin/laropiprant (the AIM-HIGH and HPS2-THRIVE studies) and ezetimibe (the IMPROVE-IT study) are already under way. |
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Authors:
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Anders G Olsson |
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Publication Detail:
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Type: Journal Article Date: 2010-09-08 |
Journal Detail:
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Title: F1000 medicine reports Volume: 2 ISSN: 1757-5931 ISO Abbreviation: F1000 Med Rep Publication Date: 2010 |
Date Detail:
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Created Date: 2010-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101506841 Medline TA: F1000 Med Rep Country: England |
Other Details:
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Languages: eng Pagination: 66 Citation Subset: - |
Affiliation:
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Department of Medicine and Health, Faculty of Health Sciences, Linköping University, Linköping and Stockholm Heart Center Bergviksvägen 48, SE-167 63 Bromma Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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