| Recent advances in glucokinase activators for the treatment of type 2 diabetes. | |
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MedLine Citation:
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PMID: 19520181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucokinase is a member of the hexokinase family of enzymes that are responsible for the phosphorylation of glucose to glucose-6-phosphate for further utilization in cells. The enzyme plays a key role in glucose homeostasis. Phosphorylation of glucose by glucokinase in the liver promotes glycogen synthesis, while in the beta-cell it results in insulin release. Activators of glucokinase increase the sensitivity of the enzyme to glucose, leading to increased insulin secretion and liver glycogen synthesis and a decrease in liver glucose output. Thus, small molecule glucokinase activators have been demonstrated to be effective glucose-lowering agents in animal models of type 2 diabetes and have advanced into clinical studies. |
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Authors:
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Manojit Pal |
Publication Detail:
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Type: Journal Article; Review Date: 2009-06-09 |
Journal Detail:
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Title: Drug discovery today Volume: 14 ISSN: 1878-5832 ISO Abbreviation: Drug Discov. Today Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9604391 Medline TA: Drug Discov Today Country: England |
Other Details:
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Languages: eng Pagination: 784-92 Citation Subset: IM |
Affiliation:
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New Drug Discovery, Matrix Laboratories Limited, Anrich Industrial Estate, Bollaram, Jinnaram Mandal, Medak District, Andhra Pradesh 502 325, India. manojitpal@rediffmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / drug effects Diabetes Mellitus, Experimental / drug therapy, physiopathology Diabetes Mellitus, Type 2 / drug therapy*, physiopathology Disease Models, Animal Enzyme Activators / pharmacology, therapeutic use* Glucokinase / drug effects*, metabolism Glucose / metabolism Humans Hypoglycemic Agents / pharmacology, therapeutic use Phosphorylation |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Enzyme Activators; 0/Hypoglycemic Agents; 50-99-7/Glucose; EC 2.7.1.2/Glucokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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