| Recent advances in the genetics of language impairment. | |
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MedLine Citation:
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PMID: 20193051 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Specific language impairment (SLI) is defined as an unexpected and persistent impairment in language ability despite adequate opportunity and intelligence and in the absence of any explanatory medical conditions. This condition is highly heritable and affects between 5% and 8% of pre-school children. Over the past few years, investigations have begun to uncover genetic factors that may contribute to susceptibility to language impairment. So far, variants in four specific genes have been associated with spoken language disorders - forkhead box P2 (FOXP2) and contactin-associated protein-like 2 (CNTNAP2) on chromosome7 and calcium-transporting ATPase 2C2 (ATP2C2) and c-MAF inducing protein (CMIP) on chromosome 16. Here, we describe the different ways in which these genes were identified as candidates for language impairment. We discuss how characterization of these genes, and the pathways in which they are involved, may enhance our understanding of language disorders and improve our understanding of the biological foundations of language acquisition. |
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Authors:
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Dianne F Newbury; Simon E Fisher; Anthony P Monaco |
Publication Detail:
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Type: Journal Article Date: 2010-01-26 |
Journal Detail:
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Title: Genome medicine Volume: 2 ISSN: 1756-994X ISO Abbreviation: Genome Med Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-20 Completed Date: 2011-07-14 Revised Date: 2011-10-24 |
Medline Journal Info:
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Nlm Unique ID: 101475844 Medline TA: Genome Med Country: England |
Other Details:
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Languages: eng Pagination: 6 Citation Subset: - |
Affiliation:
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Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK. dianne@well.ox.ac.uk. |
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