Document Detail

Recent advances in the development of graphene-based surface plasmon resonance (SPR) interfaces.
MedLine Citation:
PMID:  23314618     Owner:  NLM     Status:  Publisher    
Surface plasmon resonance (SPR) is a powerful technique for measurement of biomolecular interactions in real-time in a label-free environment. One of the most common techniques for plasmon excitation is the Kretschmann configuration, and numerous studies of ligand-analyte interactions have been performed on surfaces functionalized with a variety of biomolecules, for example DNA, RNA, glycans, proteins, and peptides. A significant limitation of SPR is that the substrate must be a thin metal film. Post-coating of the metal thin film with a thin dielectric top layer has been reported to enhance the performance of the SPR sensor, but is highly dependent on the thickness of the upper layer and its dielectric constant. Graphene is a single-atom thin planar sheet of sp2 carbon atoms perfectly arranged in a honeycomb lattice. Graphene and graphene oxide are good supports for biomolecules because of their large surface area and rich π conjugation structure, making them suitable dielectric top layers for SPR sensing. In this paper, we review some of the key issues in the development of graphene-based SPR chips. The actual challenges of using these interfaces for studying biomolecular interactions will be discussed and the first examples of the use of graphene-on-metal SPR interfaces for biological sensing will be presented.
Sabine Szunerits; Nazek Maalouli; Edy Wijaya; Jean-Pierre Vilcot; Rabah Boukherroub
Related Documents :
16375388 - Ab initio study on adsorption of hydrated na+ and cu+ cations on the cu(111) surface.
23065798 - Structure and spectroscopic aspects of water-halide ion clusters: a study based on a co...
21300088 - Self-aggregates formation and mucoadhesive property of water-soluble β-cyclodextrin gr...
21508498 - Contact planarization of ensemble nanowires.
24903068 - Bacterial community shift is induced by dynamic environmental parameters in a changing ...
16296748 - Bioadhesive properties of pegylated nanoparticles.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  -     ISSN:  1618-2650     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institut de Recherche Interdisciplinaire (IRI, USR 3078), Université Lille 1, Parc de la Haute Borne, 50 Avenue de Halley, BP 70478, 59658, Villeneuve d'Ascq, France,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Optical coherence tomography in dermatology.
Next Document:  Chromatographic and mass spectrometric fingerprinting analyses of Angelica sinensis (Oliv.) Diels-de...