Document Detail

Recent advances in combination treatments for photoaging: review of the literature.
MedLine Citation:
PMID:  20618367     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Photoaging of the skin is a condition characterized by a combination of physical findings including dyspigmentation, fine wrinkles, telangiectasias, tactile roughness, and precancerous change. A combination approach, treating these changes in skin pigmentation and texture simultaneously, is often required to ensure patient satisfaction. OBJECTIVE: To review the dermatologic literature on the use of combination treatments in photoaging using Medline. RESULTS: Review of the Medline literature identified 24 studies of combination approaches to photoaging in which physician and patient evaluation of efficacy of the treatment approaches were performed. Ten studies contained histologic evidence that combination approaches to photoaging, including nonablative and ablative laser resurfacing, topical retinoids, and topical photosensizers with lasers and light sources, produced cutaneous repair of photodamaged skin. These studies documented histologic improvement in various features of photodamaged skin, including change in epidermal and dermal thickness and stratum corneum compaction, greater type I and III collagen production, and less sunburn cell and thymine dimer formation after ultraviolet light exposure. CONCLUSIONS: Review of the literature demonstrates the progress of dermatologic science in understanding the cellular and molecular mechanisms of ultraviolet light-induced damage and in the development of novel combination approaches for repair of photodamage and prevention of cutaneous malignancy.
Emily P Tierney; C William Hanke
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  36     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  829-40     Citation Subset:  IM    
Laser and Skin Surgery Center of Indiana, Carmel, Indiana, USA.
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MeSH Terms
Botulinum Toxin Type A / therapeutic use
Combined Modality Therapy
Cosmetic Techniques*
Dermatologic Agents / therapeutic use
Laser Therapy
Neuromuscular Agents / therapeutic use
Skin Aging*
Reg. No./Substance:
0/Botulinum Toxin Type A; 0/Dermatologic Agents; 0/Neuromuscular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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