Document Detail


Recent advances in cardiac positron emission tomography in the clinical management of the cardiac patient.
MedLine Citation:
PMID:  14662094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite being primarily a research tool, positron emission tomography (PET) has seen slow but steady growth in the clinical management of the cardiac patient. The two major clinical applications of cardiac PET are regional myocardial perfusion imaging to determine the presence and severity of coronary artery disease and metabolic imaging to differentiate viable from nonviable myocardium in patients with ischemic left ventricular dysfunction. Indeed, PET with either nitrogen 13 ammonia or rubidium 82 may offer advantages over current single photon emission computed tomography approaches to assess myocardial perfusion. PET with fluorine 18 fluorodeoxyglucose is considered the current gold standard for identifying viable myocardium. Finally, the use of PET to quantify myocardial perfusion, metabolism, and innervation has led to key insights into the role of altered microvascular function, substrate metabolism, and neuronal function in a variety of cardiac disease processes.
Authors:
Robert J Gropler; Pablo Soto
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  6     ISSN:  1523-3782     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-09     Completed Date:  2004-05-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-6     Citation Subset:  IM    
Affiliation:
Cardiovascular Imaging Laboratory, Mallinckrodt Institute of Radiology, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA. GroplerR@mir.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Coronary Artery Disease / radionuclide imaging*
Coronary Vessels / physiopathology,  radionuclide imaging
Fluorodeoxyglucose F18 / diagnostic use
Heart / physiopathology,  radionuclide imaging*
Humans
Myocardium / metabolism,  pathology*
Tomography, Emission-Computed* / methods
Ventricular Dysfunction, Left / radionuclide imaging*
Chemical
Reg. No./Substance:
63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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