Document Detail


Recent advances in biomarkers for cancer diagnosis and treatment.
MedLine Citation:
PMID:  16023055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the availability of new technologies and the increased interest of medical practitioners to use molecular biomarkers in early detection and diagnosis, and in the prediction of therapeutic treatment efficacy and clinical outcomes, the academic and research institutions, as well as the pharmaceutical industry, have increased their efforts to develop novel molecular biomarkers for several human diseases, including cancer. The identification of molecular biomarkers also enables the development of a new generation of diagnostic products and to integrate diagnostics and therapeutics. This integrated approach will aid in 'individualizing' the medical practice. Here, we address issues related to the development of biomarkers, novel technological platforms used for drug development, future technologies and strategies for validating biomarkers for their clinical utility.
Authors:
Upender Manne; Rashmi-Gopal Srivastava; Sudhir Srivastava
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drug discovery today     Volume:  10     ISSN:  1359-6446     ISO Abbreviation:  Drug Discov. Today     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2006-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9604391     Medline TA:  Drug Discov Today     Country:  England    
Other Details:
Languages:  eng     Pagination:  965-76     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Alabama, USA.
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MeSH Terms
Descriptor/Qualifier:
Humans
Molecular Diagnostic Techniques / methods*,  trends
Neoplasms / diagnosis*,  drug therapy,  genetics
Reproducibility of Results
Treatment Outcome
Tumor Markers, Biological* / classification
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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