Document Detail


Recent advances in antithrombotic treatment for acute coronary syndromes.
MedLine Citation:
PMID:  24882677     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Anti-thrombotic drugs constitute the cornerstone of therapy in the management of acute coronary syndromes (ACS) and for patients undergoing percutaneous coronary intervention. Anti-thrombotic therapy during percutaneous coronary intervention for ACS has evolved substantially over the past 15 years. In the original 1996 ACC/AHA guidelines for the management of acute myocardial infarction (MI), only one antiplatelet agent (aspirin) and one anticoagulant (unfractionated heparin) were recommended as class I therapies. Much has since changed and the contemporary therapeutic armoury for the treatment of ACS reflects the pharmacological advances that have taken place. Recent developments in the medical management of ACS have been based around developing drugs with more predictable efficacy and at known drug targets. However there has also been considerable development of novel agents. New pharmacotherapies for ACS reflect efforts to improve efficacy and minimize complications by increasing target specificity and reducing inter-individual variation in therapeutic response.
Authors:
James P Howard; Sotiris Antoniou; Daniel A Jones; Andrew Wragg
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-31
Journal Detail:
Title:  Expert review of clinical pharmacology     Volume:  -     ISSN:  1751-2441     ISO Abbreviation:  Expert Rev Clin Pharmacol     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-6-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278296     Medline TA:  Expert Rev Clin Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-15     Citation Subset:  -    
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