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Recent Progresses on AI-2 Bacterial Quorum Sensing Inhibitors.
MedLine Citation:
PMID:  22320296     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Quorum sensing (QS) is a communication procedure that predominates gene expression in response to cell density and fluctuations in the neighboring environment as a result of discerning molecules termed autoinducers (AIs). It has been embroiled that QS can govern bacterial behaviors such as the secretion of virulence factors, biofilm formation, bioluminescence production, conjugation, sporulation and swarming motility. Autoinducer 2 (AI-2), a QS signaling molecule brought up to be involved in interspecies communication, exists in both gram-negative and -positive bacteria. Therefore, novel approaches to interrupt AI-2 quorum sensing are being recognized as next generation antimicrobials. In the present review article, we summarized recent progresses on AI-2 bacterial quorum sensing inhibitors and discussed their potential as the antibacterial agents.
Authors:
Peng Zhu; Minyong Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current medicinal chemistry     Volume:  19     ISSN:  1875-533X     ISO Abbreviation:  Curr. Med. Chem.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440157     Medline TA:  Curr Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  174-86     Citation Subset:  IM    
Affiliation:
Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong 250012, China. mli@sdu.edu.cn.
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