Document Detail

Recent progress in antithrombotic therapy for atrial fibrillation.
MedLine Citation:
PMID:  21088368     Owner:  NLM     Status:  MEDLINE    
Atrial fibrillation (AF) is becoming a major health care burden as elderly populations increase. The increased risk of stroke and thromboembolisms in patients with AF is well documented and anti-coagulation with adjusted-dose warfarin is highly effective in reducing stroke risk, being superior to antiplatelet agents. Despite recognition of the epidemiological problem and the sound evidence base for thromboprophylaxis, as well as major guidelines recommending treatment, anticoagulation use is still suboptimal, given the dis-utility and limitations associated with warfarin. Recent developments in thromboprophylaxis for AF include efforts for better risk stratification for predictions of thromboembolic risk. Constant efforts are underway to develop newer, less cumbersome, alternatives to warfarin with similar (or better) efficacy. This review article provides an overview of the recent progress made, the potential challenges involved and the future of these therapeutic approaches.
Selvakumar Velu; Gregory Y H Lip
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-11-13
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  18     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-27     Completed Date:  2011-10-11     Revised Date:  2011-12-06    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  257-73     Citation Subset:  IM    
University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK.
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MeSH Terms
Anticoagulants / therapeutic use*
Atrial Fibrillation / drug therapy*
Risk Assessment / trends
Stroke / etiology,  prevention & control
Thromboembolism / etiology,  prevention & control
Reg. No./Substance:

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